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Blob Novel polymorph of 5-cyanopthalide high purity inter...

Created: 2012-07-24 12:02:16

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to obtaining a new polymorph of 5-Cyanophthalide in highly pure form (99.5 to 99.99%), which is an intermediate used forthe synthesis of citalopram& escitalopram both of which are potent antidepressant drugs.Moreover this new polymorph of 5-cyanophthalide does not contain impurities liketerephthalic acid & diphthalide derivatives.        

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Blob Enantioselective method of synthesizing methylphenid...

Created: 2012-07-24 11:51:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for the preparation of enantioselective method of making methylphenidate and derivatives . The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer . Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives &...

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Blob Quality Assurance and GMP and ICH

Created: 2012-07-24 11:46:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Quality Assurance is a planned and systematic approach to generate enough confidence in the quality of the product and processes in the long run as per the specifications." In this biog you will find post related to ICH, GMP and Quality related matters.

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Blob GLIBENCLAMIDE Complexes ( Complexes of Mg,Cr,Ni,Zn a...

Created: 2012-07-24 11:33:50 | Last updated: 2012-07-24 11:33:51

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The N-acetyl derivative of β-phenethylamine is reacted with chlorosulfonic acid to form the para sulfonyl chloride derivative. This is then subjected to ammonolysis, followed by base-catalyzed removal of the acetamide. This is then acylated with 2-methoxy-5-chlorobenzoic acid chloride to give the amide intermediate. This is then reacted with cyclohexyl isocyanate to yield the sulfonylurea glibenclamide

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Blob HOW TO START ANALYTICAL METHOD DEVELOPMENT

Created: 2012-07-24 11:28:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 A bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines.The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer components. I...

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Blob DEFINITION “IMPURITY”

Created: 2012-07-24 11:18:54

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Impurities are normally generated during the formation of Active PharmaceuticalIngredients and their intermediates. Chances of their generation during Drug Productsformation are less as formulation is a physical blending process. Care is taken that theseexcipients do not react with each other to produce the degradants. They may consist oforganic and inorganic, and define levels at which impurities/degradants should beidentified.ICH Q3A covers drug substances and Q3B covers drug products. Th...

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Blob Improved process for preparing L-phenylephrine hydro...

Created: 2012-07-24 11:12:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to an improved process for preparing L-phenylephrinehydrochloride on an industrial scale    

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Blob PROCESS FOR PREPARATIN OF VITAMIN-C-Dr.krishnasarma ...

Created: 2012-07-24 11:03:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Ascorbic acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellowcrystal or powder with a slight acidic taste. It is an antiscorbutic product. On exposure to light, itgradually darkens. In the dry state, it is reasonably stable in air, but in solution it rapidlyoxidizes. Ascorbic acid (vitamin c) is freely soluble in water; sparingly soluble in alcohol;insoluble in chloroform, in ether, and in benzene. The chemical name of ascorbic acid (vitaminc) is L-ascorbic a...

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Blob Industrial process for preparation of Levetiracetam....

Created: 2012-07-24 10:59:51

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

         Levetiracetam belongs to the class of compounds used in the treatment of epilepsy so it.has huge demand in market and it is worth to develop the product.

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Blob solid-state forms of celecoxib andAN IMPROVED PROCE...

Created: 2012-07-24 10:54:47

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

          The present application provides an improved process for the preparation  of          4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide           (Celecoxib) and its purification and crystallisation to produce polymorph .  

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